Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese

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Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese

Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association ...

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Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese

The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use...

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ژورنال

عنوان ژورنال: Current Neuropharmacology

سال: 2011

ISSN: 1570-159X

DOI: 10.2174/157015911795017119